Saturday, October 20, 2012

Rutgers researchers unveil 3-D structure of 'molecular machine' that initiates DNA transcription

Rutgers researchers unveil 3-D structure of 'molecular machine' that initiates DNA transcription

Friday, October 19, 2012

An team of Rutgers University scientists led by Richard H. Ebright and Eddy Arnold has determined the three-dimensional structure of the transcription initiation complex, the key intermediate in the process by which cells read out genetic information in DNA.

In a paper to be published in Science and released online today at Science Express, the Rutgers scientists show how the "molecular machine" responsible for transcription initiation ? a protein complex that consists of the enzyme RNA polymerase and the initiation factor sigma ? recognizes a specific site on DNA preceding a gene, binds to DNA, unwinds the DNA helix, and pre-organizes the unwound DNA to enable subsequent reactions.

"Determining the structure of a functional, specific transcription initiation complex has been a goal of researchers for three decades," said Ebright, a professor in the Department of Chemistry and Chemical Biology at Rutgers, a laboratory director at the Waksman Institute of Microbiology at Rutgers, and an investigator of the Howard Hughes Medical Institute.

The structure determined by the Rutgers researchers is the structure of a transcription initiation complex from a bacterium. The structure provides a foundation for understanding bacterial transcription initiation and transcriptional regulation and provides a starting point for developing new antibacterial agents that function by inhibiting bacterial transcription. Because the transcription machineries in bacteria and higher organisms are structurally and mechanistically related, the structure also provides a framework for understanding transcription and transcriptional regulation in higher organisms, including humans.

The structure defines the interactions that RNA polymerase and sigma make with the DNA site for transcription initiation, known as the "promoter." In particular, the structure defines interactions with a segment of the promoter that RNA polymerase and sigma unwind to form single-stranded DNA (the "transcription bubble") and specific DNA sequences that RNA polymerase and sigma recognize and bind to within this segment of the promoter (the "-10 element," the "discriminator element," and a new DNA sequence identified in this work, the "core recognition element").

The structure shows that a first part of sigma recognizes the -10 element through contacts with single-stranded DNA that entail the unstacking and insertion of DNA bases of the -10 element into pockets. A second part of sigma recognizes the discriminator element through contacts with single-stranded DNA that entail the unstacking and insertion of a DNA base of the discriminator element into a pocket. A third part of sigma contacts the other strand of DNA and pre-organizes it to serve as the template for RNA synthesis. Finally, RNA polymerase recognizes the core recognition element through contacts with single-stranded DNA, unstacking and inserting a DNA base into a pocket.

"This study represents a very significant contribution to our understanding of the workings of this central macromolecular machine of gene expression," said Peter von Hippel, professor of biophysical chemistry and molecular biology at the University of Oregon, who was not part of the study. "A particular significance of this work is the very systematic way the researchers built nucleic acid scaffolds bound to various nucleic acid and protein complexes involved in the various steps of initiation and were able to show in detail how the sigma initiation factor interacts with the various individual nucleotide residues involved in the recognition of the important elements of the promoter."

"While the structures of several RNA polymerase enzymes are known, no previous structures show the polymerase, including an initiation factor and the promoter DNA, poised to begin elongation," said Peter Preusch of the National Institutes of Health's National Institute of General Medical Sciences, which partially funded the work. "This detailed three-dimensional structure informs our understanding of how transcription initiation occurs and may lead to new ways to manipulate this fundamental process for therapeutic purposes."

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Article: http://www.sciencemag.org/content/early/2012/10/18/science.1227786.full

Rutgers University: http://www.rutgers.edu

Thanks to Rutgers University for this article.

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Source: http://www.labspaces.net/124649/Rutgers_researchers_unveil___D_structure_of__molecular_machine__that_initiates_DNA_transcription

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Romney ups criticism of Obama's second-term plans

Republican presidential candidate, former Massachusetts Gov. Mitt Romney, center, talks with foreign policy adviser Dan Senor, left, and his vice presidential running mate, Rep. Paul Ryan, R-Wis., before boarding his campaign plane at Daytona International Airport, Saturday, Oct. 20, 2012, in Daytona Beach, Fla. (AP Photo/ Evan Vucci)

Republican presidential candidate, former Massachusetts Gov. Mitt Romney, center, talks with foreign policy adviser Dan Senor, left, and his vice presidential running mate, Rep. Paul Ryan, R-Wis., before boarding his campaign plane at Daytona International Airport, Saturday, Oct. 20, 2012, in Daytona Beach, Fla. (AP Photo/ Evan Vucci)

Republican vice presidential candidate, Rep. Paul Ryan, R-Wis. gestures while speaking at a campaign rally at the Valley View Campgrounds in Belmont, Ohio, Saturday, Oct. 20, 2012, where he talked about economic conditions and the coal industry. (AP Photo/Keith Srakocic)

Republican presidential candidate, former Massachusetts Gov. Mitt Romney, left, addresses supporters as his vice presidential running mate Rep. Paul Ryan, R-Wis., listens at the Daytona Beach Historic Bandshell during the Romney Ryan Victory Rally in Daytona Beach, Fla., Friday, Oct. 19, 2012. (AP Photo/Phelan M. Ebenhack)

In this photo provided by Kathy Hackshaw, President Barack Obama greets a child during a campaign rally in Fairfax, Va., Friday, Oct. 19, 2012. (AP Photo/Courtesy Kathy Hackshaw) MANDATORY CREDIT

First lady Michelle Obama speaks to Friday, October 19, 2012, during a campaign event in Racine, Wis. About 2,500 people gathered to see her speak at Memorial Hall. (AP Photo/Journal Times, Gregory Shaver)

(AP) ? Heading into the campaign's final weeks, Republican presidential candidate Mitt Romney is upping his criticism of President Barack Obama's plans for a second term, accusing the Democrat of failing to tell Americans what he would do with four more years. The Obama campaign is aggressively disputing the notion, claiming it's Romney who hasn't provided specific details to voters.

At campaign events, in a new ad and fundraising appeal out Saturday, Romney is setting up the closing weeks as a choice between what he says is a "small" campaign that's offering little new policy and his own ambitious plan to fundamentally change America's tax code and entitlement programs.

The new Romney ad criticizes the president's policies on debt, health care, taxes, energy and Medicare, arguing that Obama is simply offering more of the same. The campaign did not say where the spot would air. The fundraising appeal hits Obama for raising taxes and increasing the debt by $5.5 trillion, repeating the lack-of-agenda criticism.

"Although President Obama won't lay out his plan for a second term, we already know what it will be ? a repeat of the last four years. We can't afford four more years of crushing debt and wasteful spending," Romney says in the letter, adding he has a clear plan to put America on a path to prosperity.

Both Obama and Romney retreated from the campaign trail Saturday to bone up on foreign policy, leaving the work of courting voters to their running mates.

Vice presidential candidate Paul Ryan on Saturday continued the no-agenda theme against Obama at campaign stops near Pittsburgh and in Belmont, Ohio.

"He's not even telling you what he plans on doing," Ryan told a rain-soaked crowd of about 1,100 people at a campground in coal-rich eastern Ohio.

Obama's campaign disputes the notion that the president hasn't outlined a detailed second-term agenda, pointing to his calls for immigration reform, ending tax breaks for upper income earners, fully implementing his health care overhaul and ending the war in Afghanistan.

In a statement sent after Romney's Friday night event, Obama campaign spokesman Danny Kanner ticked through a series of policy items, calling them "just part of President Obama's agenda for a second term."

Obama, at the Democratic National Convention, called for creating 1 million manufacturing jobs over the next four years with a mix of corporate tax rate cuts and innovation and training programs. He has set a goal of cutting the growth of college tuition in half over the next 10 years. He also has called for Congress to pass proposals he made last year that include includes tax credits for companies that hire new workers and funding for local municipalities to hire more teachers, police officers and firefighters.

As for why Republicans would back the same proposals they have already voted against, Obama has told supporters he expects his re-election would "break the fever" on Capitol Hill that led to gridlock during his first term.

Vice President Joe Biden made a diagnosis of his own on Saturday, saying Ryan had caught "Romnesia," the word Obama used the day before to describe what he calls Romney's changing polices.

"That man is contagious," Biden said of Romney, to loud cheers at a campaign stop in St. Augustine, Fla. "Congressman Ryan caught it as well."

He said the Wisconsin Congressman is now giving a new explanation for cuts in the budget he oversaw and passed in the House.

The president's aides are particularly irked by the questions about Obama's second-term agenda, because they say it's Romney who has failed to provide voters with details. They point to his refusal to provide specifics about his tax plan or outline what he would replace the president's health care overhaul with if he makes good on his promise to repeal the federal law.

An independent group backing Obama, though, is trying to renew attention on Romney's tenure at the helm of the private equity firm Bain Capital. The group, Priorities USA Action, is re-airing an ad about an AMPAD plant in Marion, Ind. That spot features former employee Mike Earnest recalling being told to build a stage from which officials of the office supply company later announced mass layoffs.

He says, "It was like building my own coffin." That ad first aired in battleground states in the summer.

Romney aides have said AMPAD was a struggling business to begin with, and Bain overall created many more jobs than were lost.

That ad will air in Colorado, Florida, Iowa, Ohio, Nevada, Virginia and Wisconsin. The new campaign will be in addition to a $30 million effort against Romney policy proposals, the group said.

Monday's debate in Boca Raton, Fla., with its focus on international affairs, is the third and final between the two rivals and comes just 15 days before the election.

Obama left Friday for Camp David, the presidential hideaway in Maryland's Catoctin Mountains, where he is huddled with advisers preparing for the debate. Among those with him are White House senior adviser David Plouffe and senior campaign strategist David Axelrod. Aides say Obama was also being assisted by National Security Adviser Tom Donilon and former Obama aide Karen Dunn.

Romney was also with aides preparing for the debate, spending the weekend in Florida.

Both campaigns are heavily targeting Florida and its 29 electoral votes ? the most of any tossup state. It was the second day of a two-day Florida swing for Biden, which overlapped a two-day swing by Ryan. Romney's wife, Ann, was also in Florida Saturday and First Lady Michelle Obama planned a visit Monday, ahead of the presidential debate that night in Boca Raton. The president is planning at least two days of campaigning in Florida after the debate.

Monday's 90-minute debate will be moderated by Bob Schieffer of CBS News and the candidates will be seated at a table. Schieffer has listed five subject areas, with more time devoted to the Middle East and terrorism than any other topic.

While the economy has been the dominant theme of the election, foreign policy has attracted renewed media attention in the aftermath of the attack on the U.S. Consulate in Benghazi, Libya, that killed four Americans, including U.S. Ambassador Chris Stevens.

Obama had ranked well with the public on his handling of international issues and in fighting terrorism, especially following the death of Osama bin Laden. But the administration's response to the Libya attack and questions over levels of security at the consulate have given Romney and his Republican allies an issue with which to raise doubts about Obama's foreign policy leadership.

Romney has spent large amounts of time off the campaign trail to prepare for the upcoming foreign policy debate. Aides say the additional time preparing is well-spent even if it comes at the expense of public events.

___

Kuhnhenn reported from Washington. Associated Press writers Julie Pace and Ken Thomas in Washington and Ann Sanner in Belmont, Ohio, contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2012-10-20-Presidential%20Campaign/id-111a836a8a11433fbcc57a20e24c97a6

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South Korean Company Indicted for Theft of Trade Secrets ...

Yesterday, Kolon Industries Inc. and several of its executives and employees were indicted for allegedly engaging in a multi-year campaign to steal trade secrets related to DuPont?s Kevlar para-aramid fiber and Teijin Limited?s Twaron para-aramid fiber.?The charges were announced today by U.S. Attorney for the Eastern District of Virginia Neil H. MacBride; Assistant Attorney General Lanny A. Breuer of the Justice Department?s Criminal Division; and Jeffrey C. Mazanec, Special Agent in Charge of the FBI?s Richmond Field Office.

Headquartered in Seoul, South Korea, Kolon was indicted by a grand jury in Richmond, Virginia. ?The indictment charges Kolon with one count of conspiring to convert trade secrets, four counts of theft of trade secrets, and one count of obstruction of justice.?The indictment further seeks forfeiture of at least $225 million in proceeds from the alleged theft of trade secrets.

In addition to the corporation itself, the following Kolon executives and employees from Seoul were charged with conspiring together to steal trade secrets and obstruction of justice for deleting information from their computers:

  • Jong-Hyun Choi, 56, was a senior executive overseeing the Heracron Business Team. He allegedly met with other top executives at Kolon to develop the directives to secure consultants and directly participated in carrying out the directives.
  • In-Sik Han, 50, managed Kolon?s research and development related to Heracron and was allegedly responsible for overseeing the ?consulting? sessions with ex-DuPont employees.
  • Kyeong-Hwan Rho, 47, worked for Kolon for more than 25 years and served as the head of the Heracron Technical Team beginning in January 2008. He allegedly participated in the consulting sessions.
  • Young-Soo Seo, 48, reported to Choi and served as the general manager for the Heracron Business Team beginning in November 2006. He allegedly participated in the consulting sessions.
  • Ju-Wan Kim, 40, was a manager on the Heracron Business Team from September 2007 through February 2009 and reported to Seo. He was the main point of contact at Kolon for at least one of the ex-DuPont employees. He also participated in the consulting sessions.

The conspiracy and theft of trade secrets counts each carry a maximum penalty of 10 years in prison and a fine of $250,000 or twice the gross gain or loss for individual defendants and a fine of $5 million or twice the gross gain or loss for the corporate defendant. The obstruction of justice count carries a maximum penalty of 20 years in prison and a fine of $250,000 or twice the gross gain or loss for individual defendants and a fine of $500,000 or twice the gross gain or loss for the corporate defendant.

?Kolon is accused of engaging in a massive industrial espionage campaign that allowed it to bring Heracron quickly to the market and compete directly with Kevlar,? said U.S. Attorney MacBride. ?This country?s greatest asset is the innovation and the ingenuity and creativity of the American people. The genius of free enterprise is that companies compete on the excellence of their ideas, products, and services?not on theft. This indictment should send a strong message to companies located in the United States and around the world that industrial espionage is not a business strategy.?

?By allegedly conspiring to steal DuPont?s and Teijin?s intellectual property, Kolon threatened to undermine an economic engine at both companies,? said Assistant Attorney General Breuer. ?Developing Kevlar and Twaron was resource-intensive work and required strategic investment and ingenuity. Kolon, through its executives and employees, allegedly acted brazenly to profit off the backs of others. The Justice Department has made fighting intellectual property crime a top priority, and we will continue to aggressively prosecute IP crimes all over the country.?

?It?s critical that law enforcement aggressively investigate crimes of intellectual property theft, such as this one,? said FBI Special Agent in Charge Mazanec. ?If not, intellectual creativity and our economy will be compromised. As a member of the Department of Justice Task Force on Intellectual Property, our office will investigate any company, domestic or international, that steals confidential proprietary information for their own benefit. We will pursue those that prey on the originality and vision of hardworking businesses who conduct their own research, obtain patents, and market a successful product.?

In an attempt to defend the company, as well as distance the company and its executives from any wrongdoing, Kolon issued a press release earlier today denying the charges and promising a vigorous defense. ?The press release explained that the company ?takes the allegations made today by the U.S. Department of Justice (?DOJ?) very seriously and will defend vigorously against the charges relating to alleged trade secrets concerning DuPont?s and Teijin?s aramid fiber products.? ?The press release went on to accuse the Department of Justice with unfairly damaging the company?s reputation and impugning its own intellectual property and development efforts. ?The company expressed concern that??DOJ?s allegations undermined its freedom to benefit customers through legitimate competition in the United States and elsewhere.?

?It?s always unfortunate when companies like DuPont resort to trade secret litigation to attempt to block legitimate competition, particularly in an area of technology that is four decades old. DuPont?s aramid fiber technology is the subject of hundreds of expired patents that have been in the public domain for dozens of years for any competitor to use legitimately. It is disturbing that the DOJ would bring charges that effectively assist DuPont in improperly extending its monopoly over aramid fiber technology beyond the limited term provided by the U.S. patent laws,? says Jeff Randall of Paul Hastings LLP, counsel for Kolon. ?DuPont reaped the benefits of monopoly power to the extent permitted by law, including higher prices to consumers of aramid fiber products, for the duration of its patent coverage. Now that DuPont?s key patents have expired, competitive products such as Kolon?s Heracron? should be free to compete on the merits to the benefit of consumers in the United States and internationally,? he continued.

?Often in legitimate trade secret disputes involving the government, prosecutors will bring a criminal case, which then eliminates the need for any subsequent civil case,? Randall continued. ?That?s not what happened here. Despite its ongoing investigation since June 2007, the DOJ initially opted not to prosecute Kolon, and instead allowed DuPont to engage Kolon in more than three and a half years of civil litigation. That raises significant questions as to what DOJ now seeks to accomplish, particularly given that the legitimacy of DuPont?s civil verdict soon will be tested on appeal,? added Randall.

Factually, the dispute centers around Kolon?s product called Heracron, which is a recent entrant into the para-aramid fiber market as a competitor to products called Kevlar and Twaron. Para-aramid fibers are used to make, for example, body armor, fiberoptic cables, and automotive and industrial products. Kevlar is produced by E.I. du Pont de Nemours and Company (DuPont), one of the largest chemical companies in the United States. For decades, Kevlar has competed against Twaron, a para-aramid fiber product produced by Teijin Limited, one of the largest chemical companies in Japan.

According to the indictment, from July 2002 through February 2009, Kolon allegedly sought to improve its Heracron product by targeting current and former employees at DuPont and Teijin and hiring them to serve as consultants, then asking these consultants to reveal information that was confidential and proprietary.

The indictment alleges that in July 2002, Kolon obtained confidential information related to an aspect of DuPont?s manufacturing process for Kevlar, and within three years, Kolon had replicated it. This successful misappropriation of DuPont?s confidential information, the indictment alleges, spurred Kolon leadership to develop a multi-phase plan in November 2005 to secure additional trade secret information from its competitors by targeting people with knowledge of both pre-1990 para-aramid technology and post-1990 technologies.

Kolon is alleged to have retained at least five former DuPont employees as consultants. Kolon allegedly met with these people individually on multiple occasions from 2006 through 2008 to solicit and obtain sensitive, proprietary information that included details about DuPont?s manufacturing processes for Kevlar, experiment results, blueprints and designs, prices paid to suppliers, and new fiber technology. In cases where the consultants could not answer Kolon?s specific and detailed questions, Kolon allegedly requested the consultants to obtain the information from current employees at DuPont.

The indictment alleges that during a meeting with one consultant, a Kolon employee surreptitiously copied information from a CD the former DuPont employee had brought with him that contained numerous confidential DuPont business documents, including a detailed breakdown of DuPont?s capabilities and costs for the full line of its Kevlar products, customer pricing information, analyses of market trends, and strategies for specific Kevlar submarkets. This wealth of information was allegedly copied and dispersed among several Kolon executives and employees, and the indictment alleges that many of these documents and others associated with the consultants were deleted by the Kolon executives and employees after DuPont filed a civil suit against Kolon in 2009.

Kolon also is accused of attempting to recruit a former employee of a Teijin subsidiary, Teijin Twaron, who reported the requests for trade secret information to Teijin Twaron. Legal representatives from Teijin Twaron sent a letter to Kolon in January 2008 demanding that Kolon cease and desist from seeking to obtain trade secrets related to Twaron. After this incident, the indictment alleges that Kolon continued to try to obtain trade secrets but took additional steps to attempt to avoid detection of its actions.

The indictment alleges that, in August 2008, Kolon employees met with a current DuPont employee in a hotel room in Richmond and discussed how the DuPont employee could provide trade secrets to Kolon without leaving evidence.

The case is being prosecuted by Assistant U.S. Attorneys Timothy D. Belevetz and Kosta S. Stojilkovic of the U.S. Attorney?s Office for the Eastern District of Virginia?s Financial Crimes and Public Corruption Unit and Trial Attorney John W. Borchert of the Criminal Division?s Fraud Section and Senior Counsel Rudolfo Orjales of the Criminal Division?s Computer Crime and Intellectual Property Section.?The FBI?s Richmond Field Office is investigating this case.

This case is part of efforts being undertaken by the Department of Justice Task Force on Intellectual Property (IP Task Force) to stop the theft of intellectual property.

Source: http://www.ipwatchdog.com/2012/10/19/south-korean-company-indicted-for-theft-of-trade-secrets/id=29046/

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Friday, October 19, 2012

Italy's E-gaming Regulation Enters Next Phase | gbgc

Interview with Giulio Coraggio, Senior associate, DLA Piper Part 2

By Jana Sedlakova

Online gambling operators, particularly those who offer online bingo and the accompanying side games, are welcoming the latest news from Italy. Side games represent a significant revenue source for operators and are an important element for all online gambling services.

Giulio Coraggio, Senior Associate at DLA Piper, stated that the ?regulations of online slots is not new as those regulations were already contained in the general casino regulations. The major change is that from 3 December 2012 it will be possible for operators to launch online slots which in my view will be incredibly beneficial for the market as it will attract a number of players betting so far on non-Italian licensed websites because of the lack of availability of online slots on Italian licensed platforms. Therefore I do expect that the launch of online slots will considerably reduce the Italian black market.?

Alongside the introduction of online slot games and the new online bingo set of rules this is undoubtedly a positive turn of events for the industry. According to many, this will definitely help to revive declining revenues. This is very good news for the remote bingo market that has seen a reduction in the turnover of 27.7% compared to 2011 mainly due to the launch of cash poker and casino games. Also, this change might further boost online slot games that will be launched on the 3 December 2012 as slot games usually operate as side games of bingo games,? Coraggion added in his blog.

He commented: ?Actually the revenues in the market have increased during the last year especially because of the launch of cash poker games and casino table games. Also I expect that the launch of online slots and the fight against the black market will further increase the turnover of the market that is becoming more mature. The turnover of bingo and sports betting was substantially reduced while on the contrary the aggregate turnover of the market was increased as a consequence of the launch of casino table games and cash poker.?

The reason behind delaying the allowance of slot games in Italy until December is believed to be to give local operators time to prepare to regain competitive balance. Coraggio explained, ?There is a political reason behind this delay. Indeed, video lottery operators are worried that the launch of slots might hamper their market as online slots are games similar to those included in the current video lotteries? offering but enjoy a more tax friendly regime. The problem is however that online operators can rely on a much lower turnover and have to compete with non-Italian licensed operators targeting Italian players in breach of Italian laws. At the same time I can understand the concerns from video lottery operators given that there are some online operators that through gaming terminals located in shops (?totem?) illegally try to compete with them. Hopefully there will not be a delay in the launch of slots, but AAMS is considering implementing stringent measures to fight against totems.?

However, regarding gaining competitive advantage by the local operators, this may be ?given by the knowledge of the market, but I do not expect any regulatory advantage over European giants? Coraggio added. ?The market was long awaiting these regulations as the current regulations are very restrictive and do not allow the offering of the same game mechanic available on the .COM website. The feedback that I received from all my clients on the draft online bingo regulations was positive and the sole concern relates to the timing for their coming into force. Indeed, the regulations make reference to guidelines for the certification of the platform that are likely to be similar to those available for casino games but have not been published yet. Likewise the launch of the new bingo will require the adoption of a new bingo protocol of communication with the servers of AAMS that has not been published yet. There are some operators that have focused their business on bingo and potential delays might hamper their business strategy.?

In comparison, Stefano Sbordoni, IT Law Professor and Lawyer, Studio Sbordoni, expressed doubts that the local operators would gain advantage by the delay. ?On the contrary, unlicensed operators (those that are ? or should be ? banned by the above described ruling) will gain competitive advantage.? He added ?The fear from the relevant segment of operators of offline slot machines is that there could be a cannibalization of their market share through the setup of totems that would allow to play online slots, such confusing the player and cheating them and the Regulator. I do not share that fear.?

Some say that the driver behind permitting online slots in Italy is double sided. Firstly, to get hold of the money that is allegedly spent on websites that already offer online slots but aren?t sanctioned and secondly to use the revenue for public good, such as to provide help to the territories devastated by earthquakes. It could then be seen as an offset to the negative sided character of gambling by assisting public welfare. Regulators are now heralding the so called public interest in particular in order to upgrade the industry image that suffers greatly from its reputation and negative side effects. It has now become crucial to associate gaming with assisting the public good, whilst, importantly, the tax issues will always be ahead of all other priorities when promoting international cooperation amongst European Union?s Member States.

Despite the fact that the new regulations will undoubtedly have a positive impact on bingo there is the element of taxation that remains to be addressed for it to be successful. Coraggio explained: ?The launch of new online bingo regulations will finally make bingo a competitive product while at the moment because of the regulatory restrictions it is still considered as a niche product. However, the success of bingo games will require an additional effort from the regulator as the current 12% turnover tax regime is excessively high in order to compete with for instance online slots that enjoy a 20% gross profit tax regime and obliges operators to keep a payout too low. If the taxation of bingo is made equal to the one applicable to casino games and the minimum payout is increased to 90% as prescribed for casino games, bingo will become a very competitive game. As to online slots, the sole downside that I envisage is the time of approval of new games by AAMS, but the new decree setting out the approval process should considerably speed up the process.?

This era of legal change that Italy is undergoing in European can be described in many ways and Giulio Coraggio believes that it ?can be considered a complete maturity of the Italian market. Now that the offering of games will become equal to the one of .COM websites my view is that even the operators that were more dubious about the Italian market will apply for a license. This change might mean that operators will start a fight against non-Italian licensed operators forcing most of the operators that want to target Italian players to obtain a local license. At the same time since most of the major operators will be licensed in Italy it will become more and more dangerous for Italian players to play on non-Italian licensed platforms.?

Related posts:

  1. New Phase Of Italian E-Gaming Regulation
  2. Virgin Games enters Italian market
  3. Regulation Will Ruin Social Gaming
On October 18, 2012 ? / ? News ? / ? Comments Off

Source: http://www.gbgc.com/2012/10/italys-e-gaming-regulation-enters-next-phase/

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Dish vs. Cablevision court filing hints at a settlement, could lead to AMC's return

If you're waiting for a sign that shows like The Walking Dead are coming back to Dish Network, a court document filed Thursday might be it. According to Reuters, the document was originally filed with the title "poss. settlement" (later changed to "adj. for briefing") and set a date for October 22nd. Additionally, the New York Post reports that on Wednesday the Judge adjourned proceedings for the week. As you'll recall, Cablevision sued the satellite company over its Voom HD channels being dropped back in 2008, and is asking for $2.4 billion in damages. If the two have found a resolution, the next question would be whether this affects Dish's negotiations with Cablevision spinoff AMC Networks, which the latter claims were derailed because of its connection to Voom. If the case proceeds, Bloomberg reports Dish CEO Charlie Ergen is set to take the stand Monday -- we'll see if this can get wrapped up before Mad Men and Breaking Bad return in 2013.

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Dish vs. Cablevision court filing hints at a settlement, could lead to AMC's return originally appeared on Engadget on Fri, 19 Oct 2012 00:42:00 EDT. Please see our terms for use of feeds.

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Source: http://www.engadget.com/2012/10/19/dish-cablevision-possible-settlement-incoming-amc/

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Foodspotting Helps You Find Delicious Eats at Home or Abroad [Social Networks]

Foodspotting Helps You Find Delicious Eats at Home or Abroad Foodspotting, the social network by and for food lovers, is one of your favorite restaurant discovery apps, and now the service is putting new focus on finding tasty treats wherever you go. The service picked up a huge overhaul that makes is easier to find not just a new place to try, but a new dish to try near you.

The new Foodspotting is still a great social network, and is still full of great photos of people's eats, but the new design features tag pages full of photos and maps of different types of foods, from dishes tagged red velvet to others tagged takoyaki. You start with a global view, but it doesn't take much to hone in on your hometown and discover a new place to try something delicious, and you even see a photo of the dish before you go.

The changes are the latest in Foodspotting's series of updates across its web and mobile apps, and its attempt to position itself a bit more as a way to help you find places to eat as well as share the dishes you love. The new site is available now to try, and if you're a member, updated apps are available in the iTunes App Store and at Google Play.

Foodspotting | via The Foodspotting Blog

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/ZJqxt1YdI-Y/foodspotting-helps-you-find-delicious-eats-at-home-or-abroad

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